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Agis Pharmaceuticals, : tase.co.il buildpage ; : ishitech.co.il 0103ar6 ; is listed on the Tel-Aviv Stock Exchange. It is right after Teva Pharmaceuticals Nasdaq: TEVA ; and it is the country's second largest pharmaceutical firm. When IHTIR published the analysis on Agis, at the outset of 2003, few expected Agis that would spike up by more than 50%. It brings the valuation into focus. IHTIR feels that the company's long-term future is excellent. The pharmaceutical company expects profit growth to be continued in the first quarter of this year, in the aftermath of its excellent results for 2002. The company posted a 13% jump to NIS 1.4 billion, in revenue and a 198% leap to NIS 82.5 million in operating profit. Agis's net profit surged 178% to NIS 63 million, compared with NIS 22.6 million in 2001. The company's fourth quarter net profit was NIS 14.1 million, compared with only NIS 2.5 million in the fourth quarter of 2001. Agis expects its profit to continue growing in the first quarter of 2003, as compared with the corresponding quarter of 2002, probably at the same rate it did in the third and fourth quarters of 2002, and as compared with Q3 and Q4 in 2001. The proportion of Agis's revenue from international operations rose from 39.5% in 2001 to 50.4% in 2002. The significant shekel depreciation against the Euro contributed greatly to the surge in company profits. Agis also predicts it will receive more authorizations, to market new products in 2003, as a result of the and carisoprodol.

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Mike Wyllie is a co-founder of Plethora Solutions. He has over 25 years of experience in senior management level positions within the pharmaceutical industry with American Home Products and Pfizer. He has considerable experience in all aspects of drug discovery and development and has been involved the successful commercialisation of products including Carsura doxazosin ; and Viagra sildenafil ; . Dr. Wyllie sits on The Clinical Trial Design and Future Therapies in BPH Committees of the World Health Organisation International Consultations on Urological Disease and he is an assistant editor of the British Journal of Urology in the Sexual Medicine Section. He has over 100 publications and is named as the inventor of in excess of 80 patents and cefzil. Depression among Australian primary school students. Personality and Individual Differences 1995; 18: 57-62 Lawlor M. Suicidal ideation in adolescence as a result of bullying. The importance of asking. Modern Medicine of Ireland 2001; 31 11 ; : 43-6 Roland E. Bullying in school: three national innovations in Norwegian schools in 15 years. Aggressive Behaviour 2000; 26: 135-43 Faust J, Forehand R. Adolescent physical complaints as a function of anxiety due to familial and peer stress: a causal model. J Anxiety Disord 1994; 8: 139-53 Stanley L, Aurora T. Social exclusion amongst adolescent girls. Educational Psychology and Practice 1998; 14 2 ; : 94-100 Lagerspetz KMJ, Bjorkvist K, Berts M, King E. Group aggression among school children in three schools. Scand J Psychol 1982; 23: 45-52 Rigby K, Slee PT. Dimensions of interpersonal relations among Australian children and implications for psychological well-being. J Soc Psychol 1992; 133 1 ; : 33-42 Olweus D. Bullying in Schools: What We Know and What We Can Do. Oxford; Blackwell, 1993 Farrington DP. Understanding and preventing bullying. In: Tonry M Ed. ; . Crime and Justice. Chicago; University of Chicago, 1993; 17: 381-458 Hodges E, Perry D. Personal and interpersonal antecedents and consequences of victimisation by peers. J Personal Soc Psychol 1999; 76: 677-85.
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In a 29-week controlled BPH trial in 100 patients, CARDURA was significantly more effective than placebo in improving urinary flow rates and reducing BPH symptoms; the effect was sustained over the entire treatment period. No tolerance to the effect of CARDURA on urodynamics or BPH symptomatology was observed in patients treated for up to 4 years in open-label studies. Both hypertensive and normotensive BPH patients treated with CARDURA demonstrate statistically significant improvements in urodynamics and symptomatology compared to placebo. Pharmacokinetics After oral administration of therapeutic doses of CARDURA absorption occurs with peak blood levels at about two hours. Bioavailability is approximately 65%. Food has little or no effect on the bioavailability. Approximately 98% of the circulating drug is bound to plasma proteins. Plasma elimination is biphasic with a terminal elimination half-life of about 22 hours. There is an accumulation of plasma doxazosin levels following steady state dosing, consistent with the terminal elimination half-life. In a study of elderly hypertensive patients the pharmacokinetic parameters of doxazosin at steady state were similar to those observed in a previous study of young and elderly healthy subjects who received a single oral dose of CARDURA. In a crossover study in 24 normotensive subjects, the pharmacokinetics and safety of doxazosin were shown to be similar with morning and evening dosing regimens. CARDURA may, therefore, be administered as a single daily morning or evening dose see DOSAGE and ADMINISTRATION ; . CARDURA is extensively metabolized, mainly by O-demethylation of the quinazoline nucleus or hydroxylation of the benzodioxan moiety. Excretion is mainly via the feces with 9% of the dose excreted in urine as doxazosin 0.5% ; or metabolites. Less than 5% is excreted as the unchanged drug, mainly in the feces. The disposition of CARDURA in patients with renal insufficiency is similar to that in patients with normal renal function. Only limited data are available in patients with liver impairment and on the effects of drugs known to influence hepatic metabolism e.g., cimetidine ; see PRECAUTIONS - Use in Patients with Impaired Liver Function. Chlorthalidone a thiazide-type diuretic sold as Hygroton, Thalitone, and generic preparations, 12.5 to 25 mg day ; Doxazosin Cardura, an alpha-blocker, 2 to 8 mg day ; . The doxazosin arm of the trial was stopped in 2000 owing to an excess in the 4-year rate of heart failure, 8.13% in the doxazosin group vs 4.45% in the chlorthalidone group.3, 4 Amlodipine Norvasc, a long-acting dihydropyridine calcium channel blocker, 2.5 to 10 mg day ; . Lisinopril Prinivil, Zestril, an ACE inhibitor, 10 to 40 mg day ; . ALLHAT did not include a beta-blocker arm, as this would have added another 10, 000 patients to an already large and costly trial. Beta-blockers, like diuretics, are considered "traditional" antihypertensive agents and are of proven benefit. If the study medication did not reduce the blood pressure to below the goal of 140 90 mm and clonazepam.

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Table 2. Factors affecting response to ECP. Content executive summary 1 the market for urinary tract agents will more than double between 2004 and 2010 2 aims, scope and format of this report introduction urinary tract agent market overview, 2003-2004 1 the market for urinary tract agents utas ; was worth $ 7bn in 2003 2 flomax is the market-leading urinary tract agent 3 harnal cements tamsulosin's position as the best-selling uta 4 generic competitor looms for the fourth best-seller, proscar 5 cardura's continued success depends on us approval of cardura xl 6 detrol sales made a dramatic recovery in 2004 after disappointment in 2003 7 xatral and uroxatral going strong 8 avodart: the market's newest drug has a lucrative sideline 1 what is male pattern baldness hair loss. Medical records must substantiate the medical necessity of drug administration.
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