Industry structure and developments The Indian pharmaceutical industry is fragmented with over 15, 000 players of all sizes, the majority of them being small. It is also one of the most regulated industries in India, a feature that is seen as a hindrance to larger investments in R&D and allied activities. The rapid shift from a processbased industry to a knowledge-based one is especially challenging for an industry going through a consolidation in the face of fierce competition. Despite a price control regime, the industry performed well and invested sizably in R&D, which is expected to help it develop new and value-added products over the long-term. Opportunities The international generics market worth US$ 40 billion represents a significant long-term opportunity for Unichem, across the developed, developing and semi-developed markets. The market is likely to witness some paradigm changes: several regulations like the introduction of exclusive marketing rights, the introduction of product patents post-2005, tax exemptions on R&D expenditure and the privatisation of the insurance sector resulting in a larger medical coverage ; . Unichem expects to capitalise on this trend through increased acquisitions, deeper international operations, co-marketing, a more effective penetration of its existing therapeutic areas through new product launches and focused NDDS research. These will help the Company explore new products and markets. Outlook India will recognise product patents by 2005 under the mutually agreed guidelines of Trade Related Intellectual Property Rights TRIPS ; and the World Trade Organisation WTO ; . There is an evolution in the marketplace towards value-added, thirdgeneration therapeutic areas addressing the cardiovascular, non-steroidal anti-inflammatory drugs NSAIDs ; , psychiatric, diabetic and diagnostics areas. Unichem enjoys a significant presence in these growing therapeutic areas. It has initiated research in NDDS products. This is expected to accelerate its product development, keeping in mind the provisions of the GATT agreement. The Company is in the process of leveraging its cost-effective manufacturing capabilities to cater to the global generics markets. Its cost-effective products, relationship with the medical fraternity, distribution channels and broad product portfolio are expected to sustain value. Besides, the Company expects to accelerate the USFDA approval process. 35.
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The following table sets forth the significant worldwide human pharmaceutical and animal health net revenue by product for the three and six months ended june 30, 2003 compared with the same periods in the prior year: three months six months ended june 30, ended june 30, in millions ; products 2003 2002 2003 - effexor $63 4 $60 5 $1, 22 9 $1, 02 6 premarin family 27 6 44 protonix 31 4 19 prevnar 26 9 14 nutritionals 21 3 19 oral contraceptives 13 6 12 zosyn tazocin 14 0 7 zoton 8 6 7 benefix 6 5 synvisc 6 0 6 ativan 5 0 4 refacto 5 4 5 enbrel 6 3 rapamune 4 8 2 cordarone 7 6 alliance revenue 15 5 8 other 41 2 49 total human pharmaceuticals 2, 97 5 west nile - innovator 2 8 1 proheart 6 1 9 other 17 3 18 total animal health 21 0 19 total pharmaceuticals $3, 19 5 $3, 00 7 $6, 35 5 $6, 15 8 17 management's discussion and analysis of financial condition and results of operations three months and six months ended june 30, 2003 consumer healthcare worldwide consumer healthcare net revenue increased 12% for the 2003 second quarter and 10% for the 2003 first half due primarily to sales of alavert introduced in the 2002 fourth quarter ; and higher sales of other cough cold allergy products, advil cold & sinus, caltrate and advil.
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Table 1: Pattern of prescribed anti-hypertensive drug combinations n 138 2-drug combinations C + D Methyldopa + D Methyldopa + C Methyldopa + A Brinerdin + A Brinerdin + D 3-drug combinations Methyldopa + C + Methyldopa + A + Methyldopa + Brinerdin + D Brinerdin + C + Methyldopa + A + Methyldopa + C + Methyldopa + B + 6.5 4-drug combinations Methyldopa + B + 2.9 Methyldopa + A + 0.7 A : Angiotensin Converting enzyme inhibitors, B : Beta-blockers, C : Calcium channel blockers, D : Diuretics. Brinerdin contains Reserpine, Dihydroergocristine and Clopamide, because digitalis purpurea.
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As at 31st March 6 INVESTMENTS Long Term At Cost ; Government Securities : National Saving Certificates Trade Investments Unquoted - Fully Paid Up A. Subsidiary Companies 1 ; 4955 Previous Year 100 ; Equity Shares of Rs. 100 - each of Lekar Healthcare Ltd. 2 ; 49940 Previous Year Nil ; Equity Shares of Rs 10 - each of J B Life Science Overseas Ltd B. 5, 866 Previous Year 5, 866 ; Equity Shares of Rs. 10 - each of Bharuch Enviro Infrastructure Ltd. Unquoted - Partly Paid Up A. 4, 71, 450 Previous Year 1, 75, 965 ; Equity Shares of Rs. 10 - each of Bharuch Eco-Aqua Infrastructure Ltd. Rs. 4 - Paid Up Quoted Fully Paid Up A. 17, 300 Previous Year 7, 300 ; Equity Shares of Rs. 10 - each of Bank of India Market Value Rs.6.56, Previous Year Rs. 1.83 ; Non - Trade Investment Quoted Fully Paid Up A. 846 Previous Year 846 ; Units of Rs. 10 - each of Unit Trust of India of 1964 Scheme Repurchase Value Rs. 0.08, Previous Year Rs. 0.05 ; B. Nil Previous Year 10269 ; Equity Shares of Rs. 5 - each of Polaris Software Labs Ltd. Market Value Rs. Nil, Previous year Rs. 13.84 ; C. 1, 000 Previous Year 1000 ; Equity Shares of Rs. 2 - each of HCL Technologies Ltd. Market Value Rs. 1.52, Previous Year Rs 2.54 ; D. Nil Previous Year 20000 ; Equity shares of Rs. 10 - each of Reliance Petroleum Ltd. Market Value Nil, Previous Year Rs 5.17 ; Refer Note Below E. 1817 Previous Year Nil ; Equity Shares of Rs. 10 - each of Reliance Industries Ltd. Market value Rs 5.02 ; Refer Note Below Unquoted Fully Paid Up 1 ; 20000 Previous Year 20000 ; Equity Shares of Enviro Technology Ltd. of Rs. 10 - each 2 ; 2000 Previous Year 2000 ; Bonds of Rural Electrification Corporation of Rs. 10 - each 3 ; 12940 Previous Year 12940 ; Equity Shares of Rs.100 - each of Mcda Agro P.Ltd. 4 ; 20000 Previous Year 20000 ; 12% Cumulative Redeemable Preference Shares of Rs. 100 - each of Mcda Agro P.Ltd. 5 ; 60000 Previous Year 60000 ; Equity Shares of Panoli Enviro Technology Ltd.of Rs. 10 - each 6 ; 2000000 Previous Year 2000000 ; Equity Shares of Rs. 10 - each of Contemporary Healthcare P. Ltd. Share Application Money Less: Provision for diminution in value of investments 2003, for example, fda.
Schema Eligibility Check 1.0 2.0 3.0 Introduction Objectives Patient Selection Pretreatment Evaluations Registration Procedures Radiation Therapy Drug Therapy Surgery Other Therapy Pathology Patient Assessments Data Collection Statistical Considerations References Appendix I Appendix II Appendix III Appendix IV Appendix V Appendix VI Appendix VII Appendix VIII Appendix IX Appendix X - Sample Consent Form - Karnofsky Performance Status - Staging System - Toxicity Criteria - Adverse Reaction Reporting Guidelines - Gleason Scoring System - Treatment Diagrams - Investigator Responsibilities - Drug Handling Procedures - Pharmacy Registration Form and atomoxetine.
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