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Multiple sclerosis and hepatitis B vaccine -- no evidence of link Two large US studies that since 1976 and 1989, respectively, have monitored health-related events in a total of about 140 000 nurses, have found no association between hepatitis B vaccination and the development of multiple sclerosis. Rumours of such a link were mooted several years ago in France and more recently in the US. n.
1 500 cells per ml, identified as Synechococcus sp which present a mean relative size near 0.08 bfu d ; . For the sample from Medane mangrove Indonesia ; , FALS and red fluorescence show a complex phytoplanktonic assemblage including picoplankton, small and large eucaryotic cells with chlorophyll a e ; . The green-yellow fluorescence measured on this sample f ; allows the discrimination of two or three populations of large cells containing biliprotein pigments which were identified as filamentous cyanobacteria Oscillatoriaceae ; . The appreciation of the viability of microorganism cells is crucial to the evaluation of sanitary risks. Epifluorescent enumeration techniques have shown that bacteria of sanitary interest living in aquatic environments were still detectable several months after they could not be enumerated by culture techniques. This raises the question of cell, for example, birth control.
Alexandre Chan, PharmD, BCPS; Vivianne Shih, BSc Pharm ; Hons, BCOP; Lita Chew, MSc, BCOP Department of Pharmacy, Faculty of Science, National University of Singapore; Department of Pharmacy, National Cancer Centre, Singapore Objectives: In Singapore, National Cancer Centre NCC ; is currently the largest ambulatory oncology treatment center. The goal of this study is 1 ; to examine the prescribing patterns of antiemetics by medical oncologists at NCC for cancer patients receiving chemotherapy, 2 ; to evaluate the adherence to the institution guideline on antiemetics utilization, 3 ; to identify the risk factors that oncologists would consider when they prescribe antiemetics for chemo-naive patients and 4 ; to examine their perception of oncology pharmacists' role in antiemetics counseling. Methods: This is a single-centered, non-randomized survey conducted at NCC. Twentyseven medical oncologists in the Department of Medical Oncology DMO ; were invited to participate in this survey. Survey forms were distributed to the medical oncologists at weekly DMO and tumor board meetings in November 2006. Results: Twenty oncologists returned surveys during the study period. Most oncologists closely adhere to the institution guideline on antiemetics utilization; however, results show a trend of overprescribing acute antiemetics for low emetogenic chemotherapy regimens. Oncologists view aprepitant to be the most effective antiemetic for delayed emesis and over 70% of them would prescribe aprepitant with highly emetogenic chemotherapy regimens. Oncologists have identified anxiety, age and gender as the top three risk factors taken into consideration when they prescribe antiemetics. Majority of oncologists found pharmacists' counseling to cancer patients on antiemetics to be effective. Conclusions: Through simple surveying tools, pharmacists can examine oncologists' prescribing patterns of acute and delayed antiemetics and identify areas of antiemetics utilization that require improvement.
1. Cook IJ, Irvine EJ, Campbell D, et al. Effect of dietary fiber on symptoms and rectosigmoid motility in patients with irritable bowel syndrome. Gastroenterology 1990; 98: 66 Soltoft J, Gudmand-Hoyer E, Krag B, et al. A double-blind trial of the effect of wheat bran on symptoms of irritable bowel syndrome. Lancet 1976; 1: 270 Manning AP, Heaton KW, Harvey RF, et al. Wheat fibre and irritable bowel syndrome. Lancet 1977; 2: 417 and ultram.
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Gowin's testimony, he believes that petitioner's prior history of "[OCD and depression]14, a history of a recurrent post traumatic regional pain syndrome, recurrent headaches as well as a history of enduring significant ongoing and recent psychological stressors, " were responsible for the development of her fibromyalgia not the vaccine. Res. Ex. A at 6. further support for his position, Dr. Brenner does not believe that the sequence of events occurring after the second hepatitis B vaccine support a causal relationship between the vaccine and petitioner's insomnia and headache. Dr. Brenner does not believe that the vaccine is responsible for petitioner's trauma because "the time relationship is ridiculously short." Tr. at 131. There was not enough time intervening between when petitioner received her second vaccination and the symptoms that she reported later that day. More specifically, as noted above, petitioner testified that she was "confused and glassy eyed" just hours after the vaccination. Id. Dr. Brenner believes that there was not "time for an immune response, let alone a cytokine response to have taken place in that short . period of time." Id. After hearing and considering Dr. Brenner's testimony, Dr. Gowin continued to opine that the vaccine is "still the major contributing factor" for petitioner's injuries. Id. at 148. Although she conceded that the short time period between the administration of the second vaccine and the development of the headache was "somewhat unusual, " she believes it can be attributed to an accelerated immune response. Id. at 147-48. Dr. Brenner also testified as to what he considered a plausible explanation for the development of petitioner's severe headache after the vaccine. Noting that petitioner had developed pre-menstrual migraines in the past, Dr. Brenner testified that this indicates that petitioner has a propensity for developing headaches. Id. at 139. He believes that the development of migraines is "also associated with the development of other migraine[s] at some at some point in time." Id. More specifically, Dr. Brenner testified that "most women with pre-menstrual migraine continue to have pre-menstrual migraine until menopause but some go on and develop classic migraine, not in association with their periods." Id. Dr. Brenner, however, neither cited anything in the record indicating that petitioner had migraines in the past, nor did he provide medical literature in support of his testimony. Curiously, Dr. Brenner also testified that pre-menstrual migraine was "its own condition, " not related to other types of migraines. Id. When probed by the court as to the differences in their opinions, while Dr. Gowin opines that the severe headache and sleep deprivation triggered petitioner's fibromyalgia, Dr. Brenner sees those symptoms as the manifestation of the condition. Id. at 138. In an effort to focus the differences between the experts' opinions, the undersigned asked Dr. Brenner what his opinion would be if there was a reported connection in the medical literature between the hepatitis B vaccine and headaches and sleep deprivation. His answers, quite frankly, were confusing. At first, he responded, "[i]f I could have seen that I would have recommended handling this case.
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1. Lipman AG. Drug therapy in terminally ill patients. J Hosp Pharm 1975; 32 3 ; : 270-6. 2. Berry JI, Pulliam CC, Caiola SM, Eckel FM. Pharmaceutical services in hospices. J Hosp Pharm 1981; 38 7 ; : 1010-4. 3. Arter SG, DuBe J, Mahoney JJ. Hospice care and the pharmacist. Pharm 1987; NS27 9 ; : 32-6. 4. Bonomi AE, Shikiar R, Legro MW. Quality-of-life assessment in acute, chronic, and cancer pain: a pharmacist's guide. J Pharm Assoc Wash ; 2000; 40 3 ; : 402-16. 5. Dean TW. Pharmacist as a member of the palliative care team. Can J Hosp Pharm 1987; 40 3 ; : 95-6. 6. Hanif N. Role of the palliative care unit pharmacist. J Palliat Care 1991; 7 4 ; : 35-6. 7. Lucas C, Glare PA, Sykes JV. Contribution of a liaison clinical pharmacist to an inpatient palliative care unit. Palliat Med 1997; 11 3 ; : 209-16. 8. Wagner J, Goldstein E. Pharmacist's role in loss and grief. J Hosp Pharm 1977; 34 5 ; : 490-2. 9. Gilbar P, Stefaniuk K. The role of the pharmacist in palliative care: results of a survey conducted in Australia and Canada. J Palliat Care 2002; 18 4 ; : 287-92. 10. ASHP statement on the pharmacist's role in hospice and palliative care. J Health-Syst Pharm 2002; 59 18 ; : 1770-3. 11. Bookwalter TC. End-of-Life Care. In: Koda Kimble MA, Young L, Kradjan W, Guglielmo BJ, eds. Applied Therapeutics The Clinical Use of Drugs. Eighth Edition ed. Philadelphia, Baltimore, New York, London, Buenos Aires, Buenos Aires, Hong Kong, Sydney, Tokyo: Lippincott Williams and Wilkins; 2005: 7-1-7-6. 12. Morrison RS, Wallenstein S, Natale DK, Senzel RS, Huang LL. "We don't carry that"--failure of pharmacies in predominantly nonwhite neighborhoods to stock opioid analgesics. N Engl J Med 2000; 342 14 ; : 1023-6. Tom Bookwalter received his PharmD from the UCSF School of Pharmacy. He has attended the Harvard Program in Palliative Care Education and Practice, as well as the Ohio Northern Raabe College of Pharmacy Program in Palliative Care. Dr. Bookwalter currently serves on the ASHP Task Force on Pain and Palliative Care as well as the Palliative Care Task Force of the Society of Hospital Medicine and xenical.
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1. 2. 3. Schwartz HL, Oppenheimer JH. Pharmacol Therap 1978; 3: 349-76. Katyare SS, et al. Arch Biochem Biophys 1977; 182: 155-63. Asayama K, Kato K. Free Rad Biol Med 1990; 8: 293-303. de Martino Rosaroll P, et al. Experientia 1996; 52: 577-82. Jackowsky G, Kun E. J Biol Chem 1983; 258: 12587-93. Cesarone CF, et al. J Physiol Gastrointest Liver Physiol 2000; 279: G1219-25. Buitrago JM, Diez LC. Andrologia 1987; 19: 37-41. Kohn FM. Hautarzt 1995; 46: 507. Faraone Mennella MR, et al. J Cell Biochem 1999; 76: 20-9, because oral contraceptives.
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